Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates.

نویسندگان

  • Fidelma Fitzpatrick
  • Hilary Humphreys
  • James P O'Gara
چکیده

Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 43 4  شماره 

صفحات  -

تاریخ انتشار 2005